A new case of Echovirus 11 neonatal fulminant hepatitis involving male twins in a Northern Italy Tertiary University Hospital: Insight on a possible immunological clue

Federica Novazzi; Antonio Piralla; Simona Perniciaro; Angelo Paolo Genoni; Francesca Drago Ferrante; Federica Giardina; Guglielmo Ferrari; Laura Pellegrinelli; Nicola Clementi; Elena Pariani; Ivan Zanoni; Fausto Baldanti; Massimo Agosti; Nicasio Mancini

doi:10.1016/j.ijregi.2024.100411

A new case of Echovirus 11 neonatal fulminant hepatitis involving male twins in a Northern Italy Tertiary University Hospital: Insight on a possible immunological clue

IJID Reg. 2024 Jul 26:12:100411. doi: 10.1016/j.ijregi.2024.100411. eCollection 2024 Sep.

Authors

Federica Novazzi^{1

2}, Antonio Piralla³, Simona Perniciaro⁴, Angelo Paolo Genoni^{1

2}, Francesca Drago Ferrante², Federica Giardina⁵, Guglielmo Ferrari³, Laura Pellegrinelli⁶, Nicola Clementi⁷, Elena Pariani⁶, Ivan Zanoni⁸, Fausto Baldanti^{3

5}, Massimo Agosti⁹, Nicasio Mancini^{1

2}

Affiliations

¹ University of Insubria, Department of Medicine and Technological Innovation Varese, Varese, Italy.
² ASST Sette Laghi, Laboratory of Medical Microbiology and Virology, Varese, Italy.
³ Fondazione IRCCS Policlinico San Matteo, Microbiology and Virology Department, Pavia, Italy.
⁴ Ospedale Filippo del Ponte Ostetricia e Ginecologia, Neonatology and NICU, Del Ponte Hospital, Varese, Italy.
⁵ University of Pavia, Department of Clinical, Surgical, Diagnostic and Pediatric Sciences Pavia, Pavia, Italy.
⁶ University of Milan, Department of Biomedical Sciences for Health Milano, Milano, Italy.
⁷ IRCCS San Raffaele Hospital, Milan, Italy, Department of Biomedical Sciences for Health, Milano, Italy.
⁸ Harvard University, Boston Children's Hospital Cambridge, Cambridge, USA.
⁹ University of Insubria, Department of Medicine and Surgery, Varese, Italy.

Abstract

The European Center for Disease Prevention and Control has reported 19 cases of severe echovirus 11 infections in neonates since 2022, nine of which were fatal. We report a new fatal neonatal case that occurred in a male twin for which we evaluated the respiratory and intestinal mucosal innate immune response.

Keywords: Echovirus 11; Enterovirus; Hepatitis; Mucosal immunity; Neonatal infection.

Publication types

Case Reports