Leukocyte-associated immunoglobulin-like receptor 1 (LAIR1) is reduced with preeclampsia and small for gestational aged fetuses

Placenta. 2024 Oct:156:10-13. doi: 10.1016/j.placenta.2024.08.018. Epub 2024 Aug 29.

Abstract

Leukocyte-associated immunoglobulin-like receptor 1 (LAIR1) is an inhibitory receptor expressed on immune cells. We evaluated LAIR1 in placentas from preeclamptic or small for gestational age (SGA) pregnancies, and placental explant model (1 % O2, IL6 and TNFα, or control). LAIR1 mRNA was reduced in placentas from preeclamptic (p < 0.0001, n = 78) and SGA (p < 0.0001, n = 32) pregnancies. LAIR1 protein expression was reduced in placentas from preeclampsia (p < 0.0001, n = 43) and SGA (p = 0.009, n = 10) pregnancies. Hypoxia (1 % O2) reduced LAIR1 mRNA expression in placental explants (p = 0.008). These findings suggest hypoxia modulates LAIR1 expression in the placenta.

Keywords: FGR; Hypoxia; LAIR1; Placenta; Preeclampsia; SGA.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Female
  • Humans
  • Hypoxia / metabolism
  • Infant, Newborn
  • Infant, Small for Gestational Age*
  • Placenta* / metabolism
  • Pre-Eclampsia* / metabolism
  • Pregnancy
  • RNA, Messenger / metabolism
  • Receptors, Immunologic* / genetics
  • Receptors, Immunologic* / metabolism

Substances

  • Receptors, Immunologic
  • leukocyte-associated immunoglobulin-like receptor 1
  • RNA, Messenger