The role of SEEG in the presurgical decision-making process in MRI-normal mesial temporal lobe epilepsy

H Catenoix; K Decaestecker; M Hermier; M Chochoi; V Guinet; A Montavont; J Isnard; S Boulogne; W Szurhaj; C Haegelen; N Reyns; M Guenot; P Derambure; J Jung; S Rheims

doi:10.1016/j.neurol.2024.06.006

The role of SEEG in the presurgical decision-making process in MRI-normal mesial temporal lobe epilepsy

Rev Neurol (Paris). 2024 Aug 29:S0035-3787(24)00559-9. doi: 10.1016/j.neurol.2024.06.006. Online ahead of print.

Authors

H Catenoix¹, K Decaestecker², M Hermier³, M Chochoi⁴, V Guinet⁵, A Montavont⁵, J Isnard⁵, S Boulogne⁵, W Szurhaj⁶, C Haegelen⁷, N Reyns⁸, M Guenot⁷, P Derambure⁴, J Jung⁵, S Rheims⁵

Affiliations

¹ Department of Functional Neurology and Epileptology, Hospices Civils de Lyon and Lyon 1 University, Lyon, France; Lyon Neuroscience Research Center, Inserm U1028, CNRS UMR5292, Lyon 1 University, Lyon, France. Electronic address: helene.catenoix@chu-lyon.fr.
² Departement of Neurology, General Hospital, Valenciennes, France.
³ Department of Neuroradiology, Hospices Civils de Lyon, Lyon, France.
⁴ Department of Clinical Neurophysiology, Lille University Medical Center and EA 1046, University of Lille2, Lille, France.
⁵ Department of Functional Neurology and Epileptology, Hospices Civils de Lyon and Lyon 1 University, Lyon, France; Lyon Neuroscience Research Center, Inserm U1028, CNRS UMR5292, Lyon 1 University, Lyon, France.
⁶ Department of Clinical Neurophysiology, Amiens University Medical Center, Amiens, France.
⁷ Lyon Neuroscience Research Center, Inserm U1028, CNRS UMR5292, Lyon 1 University, Lyon, France; Department of Functional Neurosurgery, Hospices Civils de Lyon and Lyon 1 University, Lyon, France.
⁸ Department of Neurosurgery and Neurooncology, Lille University Roger Salengro Hospital, Lille, France.

PMID: 39214842
DOI: 10.1016/j.neurol.2024.06.006

Abstract

Objectives: In patients with mesial temporal lobe epilepsy (mTLE) and normal MRI, anterior temporal lobectomy sparing the hippocampus might be considered because of the risk of post-operative memory deficit. However, it is unclear whether some patients with normal MRI and non-invasive EEG and semiological pattern highly suggestive of mesial temporal seizures demonstrate a seizure onset network sparing the hippocampus, potentially warranting surgery.

Methods: A retrospective study of 17 patients with mTLE epilepsy and normal MRI who underwent SEEG. Only patients whose non-invasive presurgical data suggested an unilateral mesial temporal epileptogenic zone (EZ), as defined by combination of ictal semiology and ictal EEG during scalp video-EEG, were included. SEEG data were analyzed using both visual and quantitative approaches. Two EZ organization were defined: (i) EZ involved the hippocampus at the onset of the ictal discharge (HIP group): (ii) patients in whom a delay>1sec was observed between the seizure onset and the involvement of the hippocampus (nHIP group). Non-invasive clinical and functional imaging data, as well as post-operative outcomes, were compared across groups.

Results: Eleven patients were included in HIP group and 6 in the nHIP group. In the nHIP group, the maximal epileptogenicity was in the amygdala in five patients and in the entorhinal cortex in one. The hippocampus normalized interictal spiking activity was not different between groups. None of the patients characteristics collected during the non-invasive presurgical workup was associated with the SEEG-based organization of the EZ. Twelve patients underwent a surgical resection, including temporal cortectomy sparing hippocampus in six. Seizure and neuropsychological post-operative outcomes were similar.

Conclusion: In patients with MRI-normal mTLE, SEEG should be included in the surgical decision-making process because seizure organization cannot be predicted from non-invasive investigations. When hippocampus is not included in the EZ, temporal resection sparing the hippocampus can be considered.

Keywords: Epilepsy; Hippocampus; SEEG; Surgery.