Generic competition and prices for azelastine-fluticasone nasal spray

Akash M Bhat; Zachary M Soler; Rodney J Schlosser; George A Scangas; Alan D Workman; Vinay K Rathi

doi:10.1002/alr.23443

Generic competition and prices for azelastine-fluticasone nasal spray

Int Forum Allergy Rhinol. 2024 Aug 30. doi: 10.1002/alr.23443. Online ahead of print.

Authors

Akash M Bhat¹, Zachary M Soler², Rodney J Schlosser^{2

3}, George A Scangas⁴, Alan D Workman⁴, Vinay K Rathi⁵

Affiliations

¹ Drexel University College of Medicine, Philadelphia, Pennsylvania, USA.
² Division of Rhinology and Sinus Surgery, Department of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.
³ Department of Surgery, Ralph H. Johnson VA Medical Center, Charleston, South Carolina, USA.
⁴ Division of Rhinology, Massachusetts Eye and Ear, Boston, Massachusetts, USA.
⁵ Department of Otolaryngology-Head and Neck Surgery, The Ohio State University, Columbus, Ohio, USA.

PMID: 39212082
DOI: 10.1002/alr.23443

Abstract

The original manufacturer of azelastine‒fluticasone (AZ‒FL) prevented generic availability until 2020 via patent enforcement. Following generic availability of AZ‒FL, Medicare utilization increased and spending decreased. Retail prices for generic AZ‒FL remain high due to markup by manufacturers and pharmacies.

Keywords: Dymista; allergic; azelastine; exclusivity; fluticasone; generic; markup; patent; price; rhinitis.

Grants and funding

1R01DC019078-01A1/National Institute on Deafness and Other Communication Disorders, one of the National Institutes of Health