Structured liquids are emerging functional soft materials that combine liquid flowability with solid-like structural stability and spatial organization. Here, we delve into the chemistry and underlying principles of structured liquids, ranging from nanoparticle surfactants (NPSs) to supramolecular assemblies and interfacial jamming. We then highlight recent advancements related to the design of intricate all-liquid 3D structures and examine their reconfigurability. Additionally, we demonstrate the versatility of these soft functional materials through innovative applications, such as all-liquid microfluidic devices and liquid microreactors. We envision that in the future, the vast potential of the liquid-liquid interface combined with human creativity will pave the way for innovative platforms, exemplified by current developments like liquid batteries and circuits. Although still in its nascent stages, the field of structured liquids holds immense promise, with future applications across various sectors poised to harness their transformative capabilities.