Recompensation of Chronic Hepatitis C-Related Decompensated Cirrhosis Following Direct-Acting Antiviral Therapy: Prospective Cohort Study From a Hepatitis C Virus Elimination Program

Gastroenterology. 2024 Dec;167(7):1429-1445. doi: 10.1053/j.gastro.2024.08.018. Epub 2024 Aug 23.

Abstract

Background & aims: Chronic hepatitis C-related decompensated cirrhosis is associated with lower sustained virologic response (SVR)-12 rates and variable regression of disease severity after direct-acting antiviral agents. We assessed rates of SVR-12, recompensation (Baveno VII criteria), and survival in such patients.

Methods: Between July 2018 and July 2023, patients with decompensated chronic hepatitis C-related cirrhosis after direct-acting antiviral agents treatment were evaluated for SVR-12 and then had 6-monthly follow-up.

Results: Of 6516 patients with cirrhosis, 1152 with decompensated cirrhosis (age 53.2 ± 11.5 years; 63% men; Model for End-stage Liver Disease-Sodium [MELD-Na]: 16.5 ± 4.6; 87% genotype 3) were enrolled. SVR-12 was 81.8% after 1 course; ultimately SVR was 90.8% after additional treatment. Decompensation events included ascites (1098; 95.3%), hepatic encephalopathy (191; 16.6%), and variceal bleeding (284; 24.7%). Ascites resolved in 86% (diuretic withdrawal achieved in 24% patients). Recompensation occurred in 284 (24.7%) at a median time of 16.5 (interquartile range, 14.5-20.5) months. On multivariable Cox proportional hazards analysis, low bilirubin (adjusted hazard ratio [aHR], 0.6; 95% confidence interval [CI], 0.5-0.8; P < 0.001), international normalized ratio (aHR, 0.2; 95% CI, 0.1-0.3; P < 0.001), absence of large esophageal varices (aHR, 0.4; 95% CI, 0.2-0.9; P = 0.048), or gastric varices (aHR, 0.5; 95% CI, 0.3-0.7; P = 0.022) predicted recompensation. Portal hypertension progressed in 158 (13.7%) patients, with rebleed in 4%. Prior decompensation with variceal bleeding (aHR, 1.6; 95% CI, 1.2-2.8; P = 0.042), and presence of large varices (aHR, 2.9; 95% CI, 1.3-6.5; P < 0.001) were associated with portal hypertension progression. Further decompensation was seen in 221 (19%); 145 patients died and 6 underwent liver transplantation. A decrease in MELDNa of ≥3 was seen in 409 (35.5%) and a final MELDNa score of <10 was seen in 335 (29%), but 2.9% developed hepatocellular carcinoma despite SVR-12.

Conclusions: SVR-12 in hepatitis C virus-related decompensated cirrhosis in a predominant genotype 3 population led to recompensation in 24.7% of patients over a follow-up of 4 years in a public health setting. Despite SVR-12, new hepatic decompensation evolved in 19% and hepatocellular carcinoma developed in 2.9% of patients. (ClinicalTrials.gov, Number: NCT03488485).

Keywords: Chronic Hepatitis C; DAAs; Decompensated Cirrhosis; Direct-Acting Antivirals; HCV Elimination; Hepatitis C Virus; Punjab Model; Recompensation.

MeSH terms

  • Adult
  • Aged
  • Antiviral Agents* / therapeutic use
  • Ascites* / drug therapy
  • Ascites* / etiology
  • Cohort Studies
  • Esophageal and Gastric Varices* / diagnosis
  • Esophageal and Gastric Varices* / etiology
  • Esophageal and Gastric Varices* / virology
  • Female
  • Follow-Up Studies
  • Gastrointestinal Hemorrhage* / etiology
  • Hepacivirus / drug effects
  • Hepacivirus / genetics
  • Hepatic Encephalopathy / epidemiology
  • Hepatic Encephalopathy / etiology
  • Hepatitis C, Chronic* / complications
  • Hepatitis C, Chronic* / drug therapy
  • Hepatitis C, Chronic* / virology
  • Humans
  • Liver Cirrhosis* / diagnosis
  • Liver Cirrhosis* / drug therapy
  • Liver Cirrhosis* / virology
  • Male
  • Middle Aged
  • Prospective Studies
  • Severity of Illness Index
  • Sustained Virologic Response*
  • Treatment Outcome

Substances

  • Antiviral Agents

Associated data

  • ClinicalTrials.gov/NCT03488485