Post-Artesunate Delayed Hemolysis in Pediatric Malaria Patients in the United States

Sesh A Sundararaman; Karen L Hanze Villavicencio; Brianne Roper; Ziyi Wang; Amy K F Davis; Jonathan A Mayhew; Michelle L Wang; Nina L Tang; Vijaya L Soma; Gail F Shust; Margaret E Feeney; Indi Trehan; Jill E Weatherhead; Chandy C John; Jeffrey S Gerber; Audrey R Odom John

doi:10.1093/jpids/piae080

Post-Artesunate Delayed Hemolysis in Pediatric Malaria Patients in the United States

J Pediatric Infect Dis Soc. 2024 Nov 4;13(10):533-536. doi: 10.1093/jpids/piae080.

Authors

Sesh A Sundararaman¹, Karen L Hanze Villavicencio¹, Brianne Roper², Ziyi Wang¹, Amy K F Davis³, Jonathan A Mayhew^{4

5}, Michelle L Wang⁶, Nina L Tang⁷, Vijaya L Soma⁸, Gail F Shust⁸, Margaret E Feeney³, Indi Trehan^{6

9

10}, Jill E Weatherhead⁷, Chandy C John⁵, Jeffrey S Gerber^{1

2}, Audrey R Odom John^{1

2}

Affiliations

¹ Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
² Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
³ Department of Pediatrics at UCSF, San Francisco, California, USA.
⁴ Department of Pediatric and Adolescent Medicine, Western Michigan University School of Medicine, Kalamazoo, Michigan, USA.
⁵ Department of Pediatrics, Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
⁶ Department of Pediatrics, Univeristy of Washington School of Medicine, Seattle, Washington, USA.
⁷ Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.
⁸ Department of Pediatrics, NYU Grossman School of Medicine, New York, New York City, USA.
⁹ Department of Global Health, University of Washington, Seattle, Washington, USA.
¹⁰ Department of Epidemiology, University of Washington, Seattle, Washington, USA.

PMID: 39149792
DOI: 10.1093/jpids/piae080

Abstract

Post-artesunate delayed hemolysis (PADH) occurred in 6 of 24 children treated with artesunate for severe malaria in the United States; however, severe hemolysis requiring hospitalization or transfusion was rare. In children in the United States treated with artesunate, counseling, and symptom monitoring may be preferred to weekly laboratory surveillance for PADH.

Keywords: adverse drug reaction; artesunate; hemolytic anemia; malaria; pediatric; post-artesunate delayed hemolysis.

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MeSH terms

Antimalarials* / adverse effects
Antimalarials* / therapeutic use
Artesunate* / therapeutic use
Child
Child, Preschool
Female
Hemolysis*
Humans
Infant
Malaria / complications
Malaria / drug therapy
Male
United States / epidemiology

Substances

Artesunate
Antimalarials

Grants and funding

K24 AI113002/AI/NIAID NIH HHS/United States