Synergistic delivery of hADSC-Exos and antioxidants has inhibitory effects on UVB-induced skin photoaging

Yu Fu; Jun-Ling Xie; Wan-Ting Zhang; Xing-Liao Zhang; Xin-Min Zhang; Meng-Meng Xu; Yao-Ting Han; Rong-Qi Liu; Guang-Ming Xie; Jing Zhang; Jun Zhang

doi:10.1016/j.heliyon.2024.e34321

Synergistic delivery of hADSC-Exos and antioxidants has inhibitory effects on UVB-induced skin photoaging

Heliyon. 2024 Jul 9;10(15):e34321. doi: 10.1016/j.heliyon.2024.e34321. eCollection 2024 Aug 15.

Authors

Yu Fu¹, Jun-Ling Xie¹, Wan-Ting Zhang², Xing-Liao Zhang¹, Xin-Min Zhang², Meng-Meng Xu¹, Yao-Ting Han², Rong-Qi Liu², Guang-Ming Xie¹, Jing Zhang^{2

3}, Jun Zhang^{1

3

4}

Affiliations

¹ Research Center for Translational Medicine at East Hospital, School of Medicine, Tongji University, Shanghai, 200010, China.
² Research Center for Translational Medicine at East Hospital, School of Life Science and Technology, Tongji University, Shangha, 200010, China.
³ Tongji Lifeng Institute of Regenerative Medicine, Tongji University, Shanghai, 200092, China.
⁴ Shanghai Institute of Stem Cell Research and Clinical Translation, Shanghai, 200092, China.

Abstract

Ultraviolet B (UVB) light exposure accelerates skin photoaging. Human adipose-derived stem cell exosomes (hADSC-Exos) and some antioxidants may have anti-photoaging effects. However, it is unknown whether the combination of hADSC-Exos and antioxidants plays a synergistic role in anti-photoaging. In cellular and 3D skin models, we showed that vitamin E (VE) and hADSC-Exos were optimal anti-photoaging combinations. In vivo, VE and hADSC-Exos increased skin tightening and elasticity in UVB-induced photoaging mice Combined treatment with VE and hADSC-Exos inhibited SIRT1/NF-κB pathway. These findings contribute to the understanding of hADSC-Exos in conjunction with other antioxidants, thereby providing valuable insights for the future pharmaceutical and cosmetic industries.

Keywords: Anti-Photoaging; Antioxidants; Skin rejuvenation; Synergistic delivery; hADSC-Exos.