High precision blood lead radiogenic isotope signatures in a community exposed to Pb contaminated soils and implications for the current Pb exposure of the European population

Sci Total Environ. 2024 Nov 10:950:174763. doi: 10.1016/j.scitotenv.2024.174763. Epub 2024 Aug 2.

Abstract

Our study provides the most comprehensive dataset for high-precision radiogenic isotopes of lead (Pb) in blood for the western European population. It investigates their potential for elucidating the contribution of soil Pb to blood Pb using a human biomonitoring survey involving 81 adults and 4 children living in the urban area of Liège (Belgium). Soils in the area show moderate (median of 360 mg/kg) to high (95th percentile of 1000 mg/kg) Pb concentrations, due to former metal processing activities. Blood lead levels (BLL) measured in the study population are, on average, quantitatively consistent with a ∼ 20 % increase due to the exposure to Pb from soils, as estimated by a single-compartment biokinetic model. Consistently, its isotopic composition does not represent an endmember that fully accounts for the variability of Blood lead isotope (BLI) compositions measured in the study population. While some individuals show more thorogenic BLI ratios (relatively more enriched in 208Pb), which could be consistent with a greater exposure to local soils and/or by their country of birth, the BLI data mostly follow a trend roughly parallel to the European Standard Lead Pollution (ESLP) line, within the European leaded gasoline field, even two decades after the withdrawal of this source. Differences in BLI are probably associated with factors related to the presence of Pb in dwellings (pipes, paint) and drinking water distribution system, suggesting that the anthropogenic Pb in use, relevant to human exposure, may contain ore components of different origins, including the Australian Pb ore signature.

Keywords: Allotment garden; Biokinetic model; Epidemiology; Historical metallurgy; Isotope forensics; Urban environment.

MeSH terms

  • Adult
  • Belgium
  • Biological Monitoring / methods
  • Child
  • Environmental Exposure* / analysis
  • Environmental Exposure* / statistics & numerical data
  • Environmental Monitoring / methods
  • Humans
  • Lead Radioisotopes / analysis
  • Lead* / blood
  • Soil / chemistry
  • Soil Pollutants* / analysis
  • Soil Pollutants* / blood

Substances

  • Lead
  • Soil Pollutants
  • Lead Radioisotopes
  • Soil