Auxiliary Partial Orthotopic Liver Transplantation Is a Safe and Effective Option for Yellow Phosphorus Toxin-induced Acute Liver Failure

Sathish Kumar Krishnan; Somashekhara Hosaagrahara Ramakrishna; Selvakumar Malleeswaran; Mohan Babu Kasala; Rajanikanth Patcha; Prasanna Gopal; Joy Varghese; Karattupalayam Sampath Mouleeswaran; Ellango Appusamy; Mettu Srinivas Reddy

doi:10.1097/TP.0000000000005163

Auxiliary Partial Orthotopic Liver Transplantation Is a Safe and Effective Option for Yellow Phosphorus Toxin-induced Acute Liver Failure

Transplantation. 2024 Jul 24. doi: 10.1097/TP.0000000000005163. Online ahead of print.

Affiliations

¹ Department of HPB and Liver Transplantation Surgery, Institute of Liver Disease and Transplantation, Gleneagles Health City, Chennai, India.
² Department of Pediatric Hepatology, Institute of Liver Disease and Transplantation, Gleneagles Health City, Chennai, India.
³ Department of Liver Transplant Anaesthesia and Critical Care, Institute of Liver Disease and Transplantation, Gleneagles Health City, Chennai, India.
⁴ Department of Hepatology and Transplant Hepatology, Institute of Liver Disease and Transplantation, Gleneagles Health City, Chennai, India.
⁵ Department of Histopathology and Transplant Immunology, Institute of Liver Disease and Transplantation, Gleneagles Health City, Chennai, India.

PMID: 39044318
DOI: 10.1097/TP.0000000000005163

Abstract

Background: Ingestion of yellow phosphorus-containing rodenticides (YPR) or firecrackers is an important cause of acute liver failure (ALF) in young adults and children, particularly in South and South-East Asia and South America. Emergency liver transplantation is indicated in cases refractory to intensive supportive therapy, including low-volume plasma exchange. There are no published reports on the feasibility of auxiliary partial orthotopic liver transplantation (APOLT) for YPR-induced ALF.

Methods: Clinical details of patients undergoing APOLT for YPR-induced ALF in 1 unit are reported. Details of postoperative follow-up, native remnant regeneration, and immunosuppression withdrawal are also reported.

Results: Between January 2021 and December 2023, 3 patients (4 y, 1.5 y, and 26 y) underwent emergency living donor liver transplantation for YPR-induced ALF. All patients were refractory to supportive therapies, including therapeutic plasma exchange, and demonstrated progression of liver injury in the form of severe encephalopathy needing intubation, ventilation, and organ support. APOLT was considered because of their young age and minimal intraoperative inotropic requirement. All explants showed confluent parenchymal necrosis with microvesicular and macrovesicular steatosis. Patients were initially maintained on standard immunosuppression. Good remnant regeneration was noted on follow-up imaging in all cases, enabling gradual withdrawal of immunosuppression. Currently, 1 child has been off immunosuppression for 15 mo and 2 others are on reduced doses of immunosuppression. All patients demonstrated good liver function.

Conclusions: APOLT procedure can be an appropriate transplant option in YPR-related ALF for children and young adults without severe hemodynamic instability.