Safety Assessment of Alkanoyl Lactyl Lactate Salts as Used in Cosmetics

Int J Toxicol. 2024 Oct;43(4_suppl):108-129. doi: 10.1177/10915818241259694. Epub 2024 Jul 23.

Abstract

The Expert Panel for Cosmetic Ingredient Safety (Panel) reviewed the safety of 10 alkanoyl lactyl lactate salts. These ingredients have the surfactant function in cosmetics in common. The Panel reviewed data relevant to the safety of these ingredients, and concluded that these 10 ingredients are safe in cosmetics in the present practices of use and concentration described in the safety assessment when formulated to be nonirritating and nonsensitizing, which may be based on a quantitative risk assessment (QRA) or other accepted methodologies.

Keywords: Calcium Stearoyl Lactylate; Cosmetic Ingredient; Cosmetic Ingredient Review; Expert Panel for Cosmetic Ingredient Safety; Safety; Sodium Behenoyl Lactylate; Sodium Caproyl Lactylate; Sodium Caproyl/Lauroyl Lactylate; Sodium Cocoyl Lactylate; Sodium Cupheoyl Lactylate; Sodium Isostearoyl Lactylate; Sodium Lauroyl Lactylate; Sodium Oleoyl Lactylate; Sodium Stearoyl Lactylate.

Publication types

  • Review

MeSH terms

  • Animals
  • Consumer Product Safety*
  • Cosmetics* / chemistry
  • Cosmetics* / toxicity
  • Humans
  • Lactates / chemistry
  • Lactates / toxicity
  • Risk Assessment
  • Surface-Active Agents / chemistry
  • Surface-Active Agents / pharmacokinetics
  • Surface-Active Agents / toxicity
  • Toxicity Tests

Substances

  • Cosmetics
  • Lactates
  • Surface-Active Agents