Introduction: Calcitonin-gene related peptide (CGRP) is a vasoactive neuropeptide involved in the pathophysiology ofmigraine. CGRP has been targeted for both preventive and acute treatment of migraine.
Objective: Provide a summary of the most clinically relevant literature surrounding CGRP modulating therapies.
Methods: This update on CGRP modulating therapies includes articles selected as most clinically relevant by theauthors.
Conclusion: CGRP modulating therapies are an exciting new addition to migraine treatment given their safety andtolerability. Additionally, compared to traditional migraine preventive medication these treatments are migrainespecific.Further real-world and clinical data is ongoing to better understand these treatments that continue to gainfavor in the management of migraine.
Keywords: Calcitonin gene-related peptide; Calcitonin gene-related peptide monoclonal antibody; Calcitonin gene-related peptide receptor antagonist; Migraine treatment; Migraine without aura.
© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.