A half sandwich Ru(II)- p-cymene nitrite complex selectively induces cell death in cisplatin-resistant malignant melanoma cells

Yin-Hsuan Sun; Huey-Ling You; Manmath Narwane; Ru Xin Koi; Chai-Lin Kao; Shyng-Shiou F Yuan; Wei-Ting Liao; Tsai-Te Lu; Sodio C N Hsu

doi:10.1039/d4dt01012d

A half sandwich Ru(II)- p-cymene nitrite complex selectively induces cell death in cisplatin-resistant malignant melanoma cells

Dalton Trans. 2024 Jul 30;53(30):12620-12626. doi: 10.1039/d4dt01012d.

Authors

Yin-Hsuan Sun¹, Huey-Ling You², Manmath Narwane¹, Ru Xin Koi³, Chai-Lin Kao^{1

4}, Shyng-Shiou F Yuan^{4

5

6}, Wei-Ting Liao⁷, Tsai-Te Lu^{3

8

9}, Sodio C N Hsu^{1

4}

Affiliations

¹ Department of Medicinal and Applied Chemistry, Drug Development and Value Creation Research Centre, Kaohsiung Medical University, Kaohsiung 807, Taiwan. sodiohsu@kmu.edu.tw.
² Department of Laboratory Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan.
³ Institute of Biomedical Engineering, National Tsing Hua University, Hsinchu 300, Taiwan.
⁴ Translational Research Center, Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan.
⁵ Department of Obstetrics and Gynecology, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan.
⁶ Faculty and College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
⁷ Department of Biotechnology, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
⁸ Department of Chemistry, National Tsing Hua University, Hsinchu 300, Taiwan.
⁹ Department of Chemistry, Chung Yuan Christian University, Taoyuan 320, Taiwan.

PMID: 39010726
DOI: 10.1039/d4dt01012d

Abstract

The Ru(II)-nitrite complex, Ru4, is explored to release nitric oxide (NO) under acidic conditions and selectively induce a cytotoxic effect towards SK-MEL-28 cisplatin-resistant malignant melanoma cells. These findings suggest that targeting the tumor-associated pHe level could be an effective strategy for the drug function of Ru(II)-nitrite compounds.

MeSH terms

Antineoplastic Agents* / chemical synthesis
Antineoplastic Agents* / chemistry
Antineoplastic Agents* / pharmacology
Cell Death / drug effects
Cell Line, Tumor
Cisplatin* / chemistry
Cisplatin* / pharmacology
Coordination Complexes* / chemical synthesis
Coordination Complexes* / chemistry
Coordination Complexes* / pharmacology
Cymenes* / chemistry
Cymenes* / pharmacology
Drug Resistance, Neoplasm* / drug effects
Humans
Melanoma* / drug therapy
Melanoma* / metabolism
Melanoma* / pathology
Monoterpenes / chemistry
Monoterpenes / pharmacology
Nitric Oxide* / metabolism
Nitrites* / chemistry
Nitrites* / pharmacology
Ruthenium* / chemistry
Ruthenium* / pharmacology

Substances

Cisplatin
Ruthenium
Antineoplastic Agents
Cymenes
Nitrites
Coordination Complexes
4-cymene
Nitric Oxide
Monoterpenes