High baseline perivascular space volume in basal ganglia is associated with attention and executive function decline in Parkinson's disease

Ryan Patrick Foreman; Erin Kaye Donahue; Jared Joshua Duran; Dawn M Schiehser; Andrew Petkus; Joseph O'Neill; Daniel Phillip Holschneider; Jeiran Choupan; John Darrell Van Horn; Ece Bayram; Irene Litvan; Michael Walter Jakowec; Giselle Maria Petzinger

doi:10.1002/brb3.3607

High baseline perivascular space volume in basal ganglia is associated with attention and executive function decline in Parkinson's disease

Brain Behav. 2024 Jul;14(7):e3607. doi: 10.1002/brb3.3607.

Authors

Affiliations

¹ Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
² Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences, University of Southern California, Los Angeles, California, USA.
³ Veterans Administration San Diego Healthcare System (VASDHS), San Diego, California, USA.
⁴ Department of Psychiatry, University of California San Diego, San Diego, California, USA.
⁵ Department of Psychiatry & the Behavioral Sciences, University of Southern California, Los Angeles, California, USA.
⁶ Division of Child Psychiatry, UCLA Semel Institute for Neuroscience, Los Angeles, California, USA.
⁷ Laboratory of NeuroImaging, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
⁸ School of Data Science, University of Virginia, Charlottesville, Virginia, USA.
⁹ Department of Psychology, University of Virginia, Charlottesville, Virginia, USA.
¹⁰ Parkinson and Other Movement Disorder Center, Department of Neurosciences, University of California, San Diego, San Diego, California, USA.

Abstract

Background: Pathologic perivascular spaces (PVS), the fluid-filled compartments surrounding brain vasculature, may underlie cognitive decline in Parkinson's disease (PD). However, whether this impacts specific cognitive domains has not been investigated.

Objectives: This study examined the relationship of PVS volume at baseline with domain-specific and global cognitive change over 2 years in PD individuals.

Methods: A total of 39 individuals with PD underwent 3T T1w magnetic resonance imaging to determine PVS volume fraction (PVS volume normalized to total regional volume) within (i) centrum semiovale, (ii) prefrontal white matter (medial orbitofrontal, rostral middle frontal, and superior frontal), and (iii) basal ganglia. A neuropsychological battery included assessment of cognitive domains and global cognitive function at baseline and after 2 years.

Results: Higher basal ganglia PVS at baseline was associated with greater decline in attention, executive function, and global cognition scores.

Conclusions: While previous reports have associated elevated PVS volume in the basal ganglia with decline in global cognition in PD, our findings show such decline may affect the attention and executive function domains.

Keywords: Virchow–Robinson space.

MeSH terms

Aged
Attention* / physiology
Basal Ganglia* / diagnostic imaging
Basal Ganglia* / pathology
Basal Ganglia* / physiopathology
Cognitive Dysfunction* / diagnostic imaging
Cognitive Dysfunction* / etiology
Cognitive Dysfunction* / pathology
Cognitive Dysfunction* / physiopathology
Executive Function* / physiology
Female
Glymphatic System / diagnostic imaging
Glymphatic System / pathology
Glymphatic System / physiopathology
Humans
Magnetic Resonance Imaging*
Male
Middle Aged
Neuropsychological Tests
Parkinson Disease* / diagnostic imaging
Parkinson Disease* / pathology
Parkinson Disease* / physiopathology
White Matter / diagnostic imaging
White Matter / pathology
White Matter / physiopathology

Abstract

MeSH terms

Grants and funding