Oral transforming growth factor-beta receptor 1 inhibitor vactosertib promotes osteosarcoma regression by targeting tumor proliferation and enhancing anti-tumor immunity

Cancer Commun (Lond). 2024 Aug;44(8):884-888. doi: 10.1002/cac2.12589. Epub 2024 Jul 6.

Sung Hee Choi^{1

2}, Jay Thomas Myers¹, Suzanne Louise Tomchuck¹, Melissa Bonner³, Saada Eid¹, Daniel Tyler Kingsley³, Kristen Ashley VanHeyst^{1

2}, Seong-Jin Kim⁴, Byung-Gyu Kim^{1

2}, Alex Yee-Chen Huang^{1

2

3

5}

¹ Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
² Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
³ Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
⁴ MedPacto Inc., Seoul, Republic of Korea.
⁵ Center for Pediatric Immunotherapy, Angie Fowler AYA Cancer Institute, UH Rainbow Babies and Children's Hospital, Cleveland, Ohio, USA.

No abstract available

Publication types