Triphenylamine Sensitized 8-Dimethylaminoquinoline: An Efficient Two-Photon Caging Group for Intracellular Delivery

Chemistry. 2024 Sep 11;30(51):e202401289. doi: 10.1002/chem.202401289. Epub 2024 Aug 22.

Abstract

Triphenylamine-sensitized 8-dimethylaminoquinoline (TAQ) probes showed fair two-photon absorption and fragmentation cross sections in releasing kainate and GABA ligands. The water-soluble PEG and TEG-analogs allowed cell internalization and efficient light-gated liberation of the rhodamine reporter under UV and two-photon (NIR) irradiation conditions.

Keywords: Caging group; Drug delivery; Intracellular delivery; Light-sensitive probes; Two-photon activation.

MeSH terms

  • Aniline Compounds / chemistry
  • Fluorescent Dyes / chemistry
  • HeLa Cells
  • Humans
  • Ligands
  • Photons*
  • Polyethylene Glycols / chemistry
  • Quinolines / chemistry
  • Rhodamines / chemistry
  • gamma-Aminobutyric Acid / chemistry

Substances

  • Fluorescent Dyes
  • Rhodamines
  • gamma-Aminobutyric Acid
  • Polyethylene Glycols
  • Aniline Compounds
  • Quinolines
  • Ligands

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