Diagnostic Yield of Urine Xpert MTB/RIF Ultra in Adults With Suspected Extrapulmonary Tuberculosis

Robert Ndege; Martin Rohacek; Farida Bani; Omary Ngome; James Okuma; Mohamed Sasamalo; Dorcas Mnzava; Klaus Reither; Fiona Vanobberghen; Jerry Hella; Daniel H Paris; Maja Weisser

doi:10.1093/ofid/ofae338

Diagnostic Yield of Urine Xpert MTB/RIF Ultra in Adults With Suspected Extrapulmonary Tuberculosis

Open Forum Infect Dis. 2024 Jun 17;11(7):ofae338. doi: 10.1093/ofid/ofae338. eCollection 2024 Jul.

Authors

Robert Ndege^{1

2

3

4}, Martin Rohacek^{1

2

3

4}, Farida Bani^{1

4}, Omary Ngome¹, James Okuma^{2

3}, Mohamed Sasamalo¹, Dorcas Mnzava¹, Klaus Reither^{2

3}, Fiona Vanobberghen^{2

3}, Jerry Hella¹, Daniel H Paris^{2

3}, Maja Weisser^{1

2

3

5}

Affiliations

¹ Biomedical Research and Clinical Trials Department, Ifakara Health Institute, Ifakara, Tanzania.
² Department of Medicine, Swiss Tropical and Public Health Institute, Allschwil, Switzerland.
³ University of Basel, Basel, Switzerland.
⁴ Internal Medicine Department, St Francis Regional Referral Hospital, Ifakara, Tanzania.
⁵ Division of Infectious Diseases and Hospital Epidemiology, University Hospital, Basel, Basel, Switzerland.

Abstract

We assessed the diagnostic yield of urine GeneXpert MTB/RIF Ultra and factors associated with a positive test among adult patients suspected to have extrapulmonary tuberculosis. Urine Ultra was positive in 14% of participants with definite or probable tuberculosis. Hospitalization, disseminated tuberculosis, and human immunodeficiency virus infection were associated with a positive result.

Keywords: diagnostic yield; extrapulmonary tuberculosis; human immunodeficiency virus; tuberculosis; urine Xpert MTB/RIF Ultra.