Abstract
A multicentre double-blind crossover study of tiaprofenic acid 600 mg daily against indomethacin 75 mg daily was carried out in 68 patients with rheumatoid arthritis to compare short-term efficacy and tolerance. There were no significant differences in efficacy between the two treatments, but significantly fewer C.N.S. side-effects were associated with tiaprofenic acid treatment. Five patients withdrew during the course of the study due to side-effects and all were receiving indomethacin.
Publication types
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Clinical Trial
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Comparative Study
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Controlled Clinical Trial
MeSH terms
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Adult
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Aged
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Anti-Inflammatory Agents / adverse effects
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Anti-Inflammatory Agents / therapeutic use*
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Arthritis, Rheumatoid / drug therapy*
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Clinical Trials as Topic
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Double-Blind Method
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Female
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Humans
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Indomethacin / adverse effects
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Indomethacin / therapeutic use*
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Male
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Middle Aged
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Propionates / adverse effects
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Propionates / therapeutic use*
Substances
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Anti-Inflammatory Agents
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Propionates
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tiaprofenic acid
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Indomethacin