Effects of cognitive behavioural therapy and exposure-response prevention on brain activation in obsessive-compulsive disorder patients: systematic review and meta-analysis

Callum Stephenson; Aaron Philipp-Muller; Elnaz Moghimi; Joseph Y Nashed; Douglas J Cook; Amirhossein Shirazi; Roumen Milev; Nazanin Alavi

doi:10.1007/s00406-024-01852-6

Effects of cognitive behavioural therapy and exposure-response prevention on brain activation in obsessive-compulsive disorder patients: systematic review and meta-analysis

Eur Arch Psychiatry Clin Neurosci. 2024 Jun 27. doi: 10.1007/s00406-024-01852-6. Online ahead of print.

Authors

Callum Stephenson¹, Aaron Philipp-Muller², Elnaz Moghimi², Joseph Y Nashed², Douglas J Cook², Amirhossein Shirazi², Roumen Milev², Nazanin Alavi²

Affiliations

¹ Queen's University, Kingston, Canada. cstephenson1212@gmail.com.
² Queen's University, Kingston, Canada.

PMID: 38935215
DOI: 10.1007/s00406-024-01852-6

Abstract

Current psychotherapeutic treatments for OCD, while effective, have complex outcomes with mixed efficacy. Previous research has observed baseline brain activation patterns in OCD patients, elucidating some of the implications of this disorder. Observing the effects of evidence-based psychotherapeutics for OCD on brain activation (through MRI) may provide a more comprehensive outline of pathology. This systematic review and meta-analysis evaluated the effects of cognitive behavioural therapy (CBT) with exposure-response prevention (ERP) on brain activation in OCD patients. Academic databases were systematically searched, and the outcomes evaluated included changes in brain activation and symptom severity between baseline and post-treatment. Patients (n = 193) had confirmed OCD diagnosis and underwent protocolized CBT with ERP programs delivered by trained therapists. Participants in the CBT with ERP programs demonstrated significant improvements in symptom severity (Cohen's d = - 1.91). In general, CBT with ERP resulted in decreased activation post-treatment in the frontal (Cohen's d = 0.40), parietal (Cohen's d = 0.79), temporal (Cohen's d = 1.02), and occipital lobe (Cohen's d = 0.76), and cerebellum (Cohen's d = - 0.78). The findings support CBT with ERP's ability to improve brain activation abnormalities in OCD patients. By identifying regions that improved activation levels, psychotherapy programs may benefit from the addition of function-specific features that could improve treatment outcomes.

Keywords: Brain activation; Cognitive behavioural therapy; Functional magnetic resonance imaging; Neuroimaging; Obsessive–compulsive disorder; Psychotherapy.