New horizons of regulatory RNA

Zhongyu Zou; Jiangbo Wei; Chuan He

doi:10.1016/j.fmre.2022.12.001

New horizons of regulatory RNA

Fundam Res. 2022 Dec 9;3(5):760-762. doi: 10.1016/j.fmre.2022.12.001. eCollection 2023 Sep.

Authors

Zhongyu Zou^{1

2}, Jiangbo Wei^{1

2}, Chuan He^{1

2

3}

Affiliations

¹ Department of Chemistry, The University of Chicago, Chicago, IL 60637, United States.
² Howard Hughes Medical Institute, The University of Chicago, Chicago, IL 60637, United States.
³ Department of Biochemistry and Molecular Biology and Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL 60637, United States.

Abstract

Genetic information flows from DNA to protein through RNA in the central dogma. Different RNA species are known to accomplish essential tasks of protein encoding (mRNAs), amino acid loading (tRNAs), and translation machinery assembly (rRNAs). However, on top of these well-known roles, RNAs are central to various cellular regulatory pathways. Here we summarize newly emerging regulatory functions of RNA, specifically focusing on regulations through RNA modifications, RNP granules, and chromatin-associated regulatory RNA. In addition to being an essential building block of the central dogma, RNA can be critical to the regulation of many cellular processes.

Keywords: Chromatin-associated regulatory RNA, Repetitive elements; RNA modifications; RNA-mediated regulation; RNP granules.

Publication types

Review