Homozygosity for R47H in TREM2 and the Risk of Alzheimer's Disease

N Engl J Med. 2024 Jun 20;390(23):2217-2219. doi: 10.1056/NEJMc2314334.
No abstract available

Publication types

  • Letter

MeSH terms

  • Aged
  • Alzheimer Disease* / ethnology
  • Alzheimer Disease* / genetics
  • Alzheimer Disease* / metabolism
  • Apolipoproteins E / metabolism
  • Cholesterol, LDL / metabolism
  • Clusterin / metabolism
  • Female
  • Genetic Predisposition to Disease / genetics
  • Homozygote
  • Humans
  • Male
  • Membrane Glycoproteins* / genetics
  • Membrane Glycoproteins* / metabolism
  • Mutation, Missense
  • Receptors, Immunologic* / genetics
  • Receptors, Immunologic* / metabolism

Substances

  • Apolipoproteins E
  • Cholesterol, LDL
  • Clusterin
  • Membrane Glycoproteins
  • Receptors, Immunologic
  • TREM2 protein, human