Cardiopulmonary exercise testing and the 2022 definition of pulmonary hypertension

Dirk Habedank; Till Ittermann; Sabine Kaczmarek; Beate Stubbe; Alexander Heine; Anne Obst; Ralf Ewert

doi:10.1002/pul2.12398

Cardiopulmonary exercise testing and the 2022 definition of pulmonary hypertension

Pulm Circ. 2024 Jun 17;14(2):e12398. doi: 10.1002/pul2.12398. eCollection 2024 Apr.

Authors

Dirk Habedank^{1

2}, Till Ittermann³, Sabine Kaczmarek², Beate Stubbe², Alexander Heine², Anne Obst², Ralf Ewert²

Affiliations

¹ Clinical Medicine Department Cardiology DRK Kliniken Berlin Köpenick Berlin Germany.
² Department of Internal Medicine B-Cardiology, Intensive Care, Pulmonary Medicine and Infectious Diseases University Medicine Greifswald Greifswald Germany.
³ Department SHIP Clinical-Epidemiological Research, Institute for Community Medicine University Medicine Greifswald Greifswald Germany.

Abstract

Parameters of cardiopulmonary exercise testing significantly discriminate between healthy subjects and patients with pulmonary hypertension (PH), also according to the new 2022 definition of pulmonary hypertension (mean pulmonary arterial pressure mPAP > 20 mmHg). The cut-offs indicating on PH were peakVO₂ ≤ 16.7 mL/min/kg (Youden-Index YI = 0.79), p_etCO₂@AT ≤ 34 mmHg (YI = 0.67), and VE/VCO₂@AT ≤ 30 (YI = 0.76).

Keywords: VE/VCO2@AT; cardiopulmonary exercise; peakVO2; petCO2@AT; pulmonary hypertension.