The Clinical and Histological Intersection of Cardiac Sarcoidosis and Giant Cell Myocarditis

Toishi Sharma; Kramer Wahlberg; Friederike Keating; Ahmed Harhash; Leslie T Cooper Jr

doi:10.7759/cureus.59783

The Clinical and Histological Intersection of Cardiac Sarcoidosis and Giant Cell Myocarditis

Cureus. 2024 May 7;16(5):e59783. doi: 10.7759/cureus.59783. eCollection 2024 May.

Authors

Toishi Sharma¹, Kramer Wahlberg¹, Friederike Keating¹, Ahmed Harhash¹, Leslie T Cooper Jr²

Affiliations

¹ Cardiology, University of Vermont, Burlington, USA.
² Internal Medicine, Mayo Clinic, Jacksonville, USA.

Abstract

The clinical and imaging features of cardiac sarcoidosis (CS) and giant cell myocarditis (GCM) are occasionally indistinguishable. This is a case of heart block and ventricular tachycardia where cardiac MRI, fluorodeoxyglucose positron emission tomography (FDG-PET) and biopsy revealed intermediate clinicohistologic phenotype between CS and GCM. This highlights gaps in the management of overlap conditions.

Keywords: biopsy; cardiac sarcoidosis; giant cell myocarditis; histology; management; overlap; pet scans.

Publication types

Case Reports