Manganese(II) promotes prebiotically plausible non-enzymatic RNA ligation reactions

Ziwei Liu; Clancy Zhijian Jiang; Andrew D Bond; Nicholas J Tosca; John D Sutherland

doi:10.1039/d4cc01086h

Manganese(II) promotes prebiotically plausible non-enzymatic RNA ligation reactions

Chem Commun (Camb). 2024 Jun 20;60(51):6528-6531. doi: 10.1039/d4cc01086h.

Authors

Ziwei Liu^{1

2}, Clancy Zhijian Jiang², Andrew D Bond³, Nicholas J Tosca², John D Sutherland¹

Affiliations

¹ MRC-Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK.
² Department of Earth Sciences, University of Cambridge, Downing Street, CB2 3EQ, UK. zwl25@cam.ac.uk.
³ Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW, UK.

Abstract

Using different prebiotically plausible activating reagents, the RNA ligation yield was significantly increased in the presence of Mn(II). The mechanism of the activation reaction has been investigated using 5'-AMP as an analogue.

MeSH terms

Manganese* / chemistry
Prebiotics
RNA* / chemistry

Substances

Manganese
RNA
Prebiotics