Impact of Body Composition on Esophagogastric Junction Opening Measures: Discordant FLIP and Manometric Findings Are More Common With Increased Body Mass Index

Ryan Flanagan; Mayssan Muftah; Brent Hiramoto; Jennifer X Cai; Walter W Chan

doi:10.14309/ajg.0000000000002823

Impact of Body Composition on Esophagogastric Junction Opening Measures: Discordant FLIP and Manometric Findings Are More Common With Increased Body Mass Index

Am J Gastroenterol. 2024 May 2:10.14309/ajg.0000000000002823. doi: 10.14309/ajg.0000000000002823. Online ahead of print.

Authors

Ryan Flanagan^{1

2}, Mayssan Muftah^{1

2}, Brent Hiramoto^{1

2}, Jennifer X Cai^{1

2}, Walter W Chan^{1

2}

Affiliations

¹ Center for Gastrointestinal Motility, Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Boston, Massachusetts, USA.
² Harvard Medical School, Boston, Massachusetts, USA.

PMID: 38775971
PMCID: PMC11530403 (available on 2025-11-02)
DOI: 10.14309/ajg.0000000000002823

Abstract

Introduction: Increased intra-abdominal pressure in patients with elevated body mass index (BMI) may affect measurements of esophagogastric junction (EGJ) opening.

Methods: Findings from adult patients who underwent both impedance planimetry with functional luminal imaging probe (FLIP) and high-resolution manometry (HRM) were compared by BMI.

Results: Among patients with no EGJ outflow obstruction on HRM, abnormal EGJ classifications on FLIP were more common among those with elevated than normal BMI (61.1% vs 31.6%, P = 0.037).

Discussion: Discordant results between FLIP and HRM on EGJ opening are more common in patients with elevated BMI. Body composition may impact EGJ function and measures on current testing modalities.

Abstract

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