Impact of environmental pollutants on pediatric brain tumor incidence in New Jersey

Clin Neurol Neurosurg. 2024 Jul:242:108318. doi: 10.1016/j.clineuro.2024.108318. Epub 2024 May 7.

Abstract

Objective: The relationship between environmental contaminants and brain tumor incidence in adults has been thoroughly explored but research into how these contaminants affect pediatric brain tumor (PBT) incidence has not been explored. Children, typically having more limited geographical movement and thus more consistent environmental contaminant exposure, might offer more reliable insights into which environmental contaminants affect the incidence of brain tumors. The present study is the first to focus on exploring whether a possible association exists between the incidence of PBTs and exposure to environmental pollutants in New Jersey (NJ).

Methods: Linear regressions were run between PBT incidence and the concentration of air quality pollutants such as Ozone (O3), Particulate Matter 2.5 (PM2.5), Particulate Matter 10 (PM10), and Carbon Monoxide (CO). Similarly, linear regressions were run between PBT incidence and Elevated Blood Lead Levels (BLL).

Results: The study observed a significant positive relationship between O3 and PBT incidence (β = 0.34, p = 0.028). However, the relationship between PBT incidence, and environmental pollutants such as CO (β = 0.0047, p = 0.098), PM2.5 (β = -0.2624, p = 0.74), and PM10 (β = -0.7353, p = 0.073) were found to be nonsignificant. For elevated BLL, nonsignificant relationships with PBT incidence were observed at 10-14 µg/dL (β = -39.38, p = 0.30), 15-19 µg/dL (β = -67.00, p = 0.21), and 20-44 µg/dL (β = -201.98, p = 0.12).

Conclusions: The results indicate a possible impact of O3 on the incidence of PBTs in NJ. In contrast to the significant links found in prior studies of adult brain tumors, the associations between PBT occurrence and particulate matter were not significant. These findings highlight the importance of further investigating how environmental factors, especially O3, relate to PBTs.

Keywords: Air pollutants; Environment; Income; Lead; Ozone; Particulate Matter; Pediatric brain tumors.

MeSH terms

  • Adolescent
  • Air Pollutants / adverse effects
  • Brain Neoplasms* / chemically induced
  • Brain Neoplasms* / epidemiology
  • Child
  • Child, Preschool
  • Environmental Exposure* / adverse effects
  • Environmental Pollutants / adverse effects
  • Female
  • Humans
  • Incidence
  • Infant
  • Male
  • New Jersey / epidemiology
  • Ozone / adverse effects
  • Particulate Matter / adverse effects

Substances

  • Environmental Pollutants
  • Particulate Matter
  • Air Pollutants
  • Ozone