Inspiration4 data access through the NASA Open Science Data Repository

Lauren M Sanders; Kirill A Grigorev; Ryan T Scott; Amanda M Saravia-Butler; San-Huei Lai Polo; Rachel Gilbert; Eliah G Overbey; JangKeun Kim; Christopher E Mason; Sylvain V Costes

doi:10.1038/s41526-024-00393-5

Inspiration4 data access through the NASA Open Science Data Repository

NPJ Microgravity. 2024 May 14;10(1):56. doi: 10.1038/s41526-024-00393-5.

Authors

Lauren M Sanders^{1

2}, Kirill A Grigorev^{1

2}, Ryan T Scott^{1

3}, Amanda M Saravia-Butler^{1

3}, San-Huei Lai Polo^{1

3}, Rachel Gilbert^{1

3}, Eliah G Overbey^{4

5

6}, JangKeun Kim^{4

5}, Christopher E Mason^{4

5

7}, Sylvain V Costes⁸

Affiliations

¹ Space Biosciences Research Branch, NASA Ames Research Center, Moffett Field, CA, USA.
² Blue Marble Space, Seattle, WA, USA.
³ KBR, Houston, TX, USA.
⁴ Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.
⁵ The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.
⁶ Center for STEM, University of Austin, Austin, TX, USA.
⁷ The WorldQuant Initiative for Quantitative Prediction, Weill Cornell Medicine, New York, NY, USA.
⁸ Space Biosciences Research Branch, NASA Ames Research Center, Moffett Field, CA, USA. sylvain.v.costes@nasa.gov.

Abstract

The increasing accessibility of commercial and private space travel necessitates a profound understanding of its impact on human health. The NASA Open Science Data Repository (OSDR) provides transparent and FAIR access to biological studies, notably the SpaceX Inspiration4 (I4) mission, which amassed extensive data from civilian astronauts. This dataset encompasses omics and clinical assays, facilitating comprehensive research on space-induced biological responses. These data allow for multi-modal, longitudinal assessments, bridging the gap between human and model organism studies. Crucially, community-driven data standards established by NASA's OSDR Analysis Working Groups empower artificial intelligence and machine learning to glean invaluable insights, guiding future mission planning and health risk mitigation. This article presents a concise guide to access and analyze I4 data in OSDR, including programmatic access through GLOpenAPI. This pioneering effort establishes a precedent for post-mission health monitoring programs within space agencies, propelling research in the burgeoning field of commercial space travel's impact on human physiology.