Deactivation of LVAD support for myocardial recovery-surgical perspectives

J Heart Lung Transplant. 2024 Sep;43(9):1489-1500. doi: 10.1016/j.healun.2024.05.005. Epub 2024 May 12.

Abstract

Left ventricular assist devices (LVADs) are excellent therapies for advanced heart failure patients either bridged to transplant or for lifetime use. LVADs also allow for reverse remodeling of the failing heart that is often associated with functional improvement. Indeed, growing enthusiasm exists to better understand this population of patients, whereby the LVAD is used as an adjunct to mediate myocardial recovery. When patients achieve benchmarks suggesting that they no longer need LVAD support, questions related to the discontinuation of LVAD therapy become front and center. The purpose of this review is to provide a surgical perspective on the practical and technical issues surrounding LVAD deactivation.

Keywords: VAD; decommissioning; explant; heart failure; mechanical circulatory support; myocardial recovery.

Publication types

  • Review

MeSH terms

  • Heart Failure* / physiopathology
  • Heart Failure* / surgery
  • Heart Failure* / therapy
  • Heart Transplantation
  • Heart-Assist Devices*
  • Humans
  • Recovery of Function*
  • Ventricular Remodeling / physiology
  • Withholding Treatment