Peptide libraries: from epitope mapping to in-depth high-throughput analysis

Abstract

Peptide arrays are a valuable instrument in the characterization of protein-protein interactions (PPIs) and immunogenic regions. New methods were developed to exploit the high-throughput potential of peptide arrays to obtain more in-depth information, replacing traditional resource-intensive experiments. Here, we discuss the recent advances in peptide-array-based technologies and the remaining challenges.

Keywords: epitope mapping; peptide arrays; peptide libraries; peptide scanning; protein–protein interactions.