Albuterol-budesonide fixed-dose combination rescue inhaler for asthma: a plain language summary of the MANDALA study

Alberto Papi; Bradley E Chipps; Richard Beasley; Reynold A Panettieri Jr; Elliot Israel; Mark Cooper; Lynn Dunsire; Allison Jeynes-Ellis; Robert Rees; Frank C Albers; Christy Cappelletti

doi:10.1177/17534666241232264

Albuterol-budesonide fixed-dose combination rescue inhaler for asthma: a plain language summary of the MANDALA study

Ther Adv Respir Dis. 2024 Jan-Dec:18:17534666241232264. doi: 10.1177/17534666241232264.

Authors

Affiliations

¹ Department of Respiratory Medicine, University of Ferrara Medical School, Ferrara, Italy.
² The Capital Allergy and Respiratory Disease Center, Sacramento, CA, USA.
³ The Medical Research Institute of New Zealand; Capital and Coast District Health Board, and Victoria University of Wellington, Wellington, New Zealand.
⁴ Rutgers Institute for Translational Medicine and Science; Child Health Institute of New Jersey, Rutgers, The State University of New Jersey, New Brunswick, NJ, USA.
⁵ Brigham and Women's Hospital, Harvard Medical School, Boston, USA.
⁶ BioPharmaceuticals Research and Development, AstraZeneca, Cambridge, UK.
⁷ Avillion, London, UK.
⁸ Avillion, Northbrook, IL, USA.
⁹ BioPharmaceuticals Research and Development, AstraZeneca, Durham, NC, USA.

Abstract

What is this summary about?This summary describes the results of a clinical study called MANDALA that was published in the New England Journal of Medicine in 2022. In the MANDALA study, researchers looked at a new asthma rescue inhaler that contains both albuterol and budesonide in a single inhaler (known as albuterol-budesonide, AIRSUPRA™). This summary describes the results for people aged 18 yearsand older who took part in the study.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Administration, Inhalation
Adolescent
Adult
Aged
Albuterol* / administration & dosage
Anti-Asthmatic Agents / administration & dosage
Asthma* / drug therapy
Bronchodilator Agents* / administration & dosage
Budesonide* / administration & dosage
Drug Combinations*
Female
Humans
Male
Middle Aged
Nebulizers and Vaporizers*
Treatment Outcome
Young Adult

Substances

Albuterol
Drug Combinations
Bronchodilator Agents
Budesonide
Anti-Asthmatic Agents