Expansion of the Genotypic and Phenotypic Spectrum of ASH1L-Related Syndromic Neurodevelopmental Disorder

Genes (Basel). 2024 Mar 28;15(4):423. doi: 10.3390/genes15040423.

Abstract

Pathogenic ASH1L variants have been reported in probands with broad phenotypic presentations, including intellectual disability, autism spectrum disorder, attention deficit hyperactivity disorder, seizures, congenital anomalies, and other skeletal, muscular, and sleep differences. Here, we review previously published individuals with pathogenic ASH1L variants and report three further probands with novel ASH1L variants and previously unreported phenotypic features, including mixed receptive language disorder and gait disturbances. These novel data from the Brain Gene Registry, an accessible repository of clinically derived genotypic and phenotypic data, have allowed for the expansion of the phenotypic and genotypic spectrum of this condition.

Keywords: ASH1L; Brain Gene Registry; ClinGen; GenomeConnect; autism spectrum disorder; histone methyltransferase; intellectual disability; neurodevelopmental disorder; syndromic complex neurodevelopmental disorder.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review
  • Research Support, N.I.H., Extramural
  • Case Reports

MeSH terms

  • Adolescent
  • Autism Spectrum Disorder / genetics
  • Autism Spectrum Disorder / pathology
  • Child
  • Child, Preschool
  • DNA-Binding Proteins / genetics
  • Female
  • Genotype
  • Histone-Lysine N-Methyltransferase* / genetics
  • Humans
  • Intellectual Disability / genetics
  • Intellectual Disability / pathology
  • Male
  • Mutation
  • Neurodevelopmental Disorders* / genetics
  • Neurodevelopmental Disorders* / pathology
  • Phenotype*
  • Transcription Factors / genetics

Substances

  • Histone-Lysine N-Methyltransferase
  • ASH1L protein, human
  • DNA-Binding Proteins
  • Transcription Factors