High efficacy of CD19 CAR T cells in patients with transformed Waldenström macroglobulinemia

Eric Durot; Damien Roos-Weil; Adrien Chauchet; Justine Decroocq; Roberta Di Blasi; Thomas Gastinne; Hedi Bensaber; Morgane Cheminant; Caroline Jacquet; Stéphanie Guidez; François-Xavier Gros; Emmanuel Bachy; Arthur Coste; Pascale Cony-Makhoul; Steven P Treon; Alain Delmer; Ran Reshef; Steven Le Gouill; Jorge J Castillo; Roch Houot

doi:10.1182/blood.2024024452

High efficacy of CD19 CAR T cells in patients with transformed Waldenström macroglobulinemia

Blood. 2024 Jun 27;143(26):2804-2807. doi: 10.1182/blood.2024024452.

Authors

Eric Durot¹, Damien Roos-Weil², Adrien Chauchet³, Justine Decroocq⁴, Roberta Di Blasi⁵, Thomas Gastinne⁶, Hedi Bensaber⁷, Morgane Cheminant⁸, Caroline Jacquet⁹, Stéphanie Guidez¹⁰, François-Xavier Gros¹¹, Emmanuel Bachy¹², Arthur Coste¹, Pascale Cony-Makhoul¹³, Steven P Treon¹⁴, Alain Delmer¹, Ran Reshef¹⁵, Steven Le Gouill¹⁶, Jorge J Castillo¹⁴, Roch Houot¹⁷

Affiliations

¹ Department of Hematology, University Hospital of Reims, Reims, France.
² Sorbonne Université, Hematology, Pitié-Salpêtrière Hospital, Paris, France.
³ Department of Hematology, University Hospital of Besançon, Besançon, France.
⁴ Department of Hematology, Hôpital Cochin, Paris, France.
⁵ Department of Hematology, Hôpital Saint Louis, Paris, France.
⁶ Department of Hematology, University Hospital of Nantes, Nantes, France.
⁷ Department of Hematology, University Hospital of Clermont-Ferrand, Clermont-Ferrand, France.
⁸ Department of Hematology, Hôpital Necker, Paris, France.
⁹ Department of Hematology, University Hospital of Nancy, Nancy, France.
¹⁰ Department of Hematology, University Hospital of Poitiers, Poitiers, France.
¹¹ Department of Hematology, University Hospital of de Bordeaux, Bordeaux, France.
¹² Department of Hematology, Hospices Civils de Lyon, Pierre Bénite, Lyon, France.
¹³ Medical and Scientific Department, Lymphoma Academic Research Organisation, Hôpital Lyon-Sud, Pierre-Bénite, France.
¹⁴ Bing Center for Waldenström Macroglobulinemia, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.
¹⁵ Division of Hematology/Oncology and Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY.
¹⁶ Department of Hematology, Institut Curie, Paris, France.
¹⁷ Department of Hematology, University Hospital of Rennes, Rennes, France.

PMID: 38669635
DOI: 10.1182/blood.2024024452

Abstract

Histologic transformation of Waldenström macroglobulinemia (HT-WM) carries a poor prognosis with standard treatments. Here, we report the first series of HT-WM treated with chimeric antigen receptor T cells showing a high efficacy and no unexpected toxicity.

MeSH terms

Aged
Antigens, CD19* / immunology
Female
Humans
Immunotherapy, Adoptive* / methods
Male
Middle Aged
Receptors, Chimeric Antigen / immunology
T-Lymphocytes / immunology
T-Lymphocytes / pathology
Treatment Outcome
Waldenstrom Macroglobulinemia* / immunology
Waldenstrom Macroglobulinemia* / pathology
Waldenstrom Macroglobulinemia* / therapy

Substances

Antigens, CD19
Receptors, Chimeric Antigen