Inhalation of 2, 4-di-tert-butylphenol-Loaded micelles suppresses respiratory syncytial virus infection in mice

Antiviral Res. 2024 Jun:226:105880. doi: 10.1016/j.antiviral.2024.105880. Epub 2024 Apr 10.

Abstract

Human respiratory syncytial virus (RSV) is a common cause of respiratory infections in infants, young children, and elderly people. However, there are no effective treatments or vaccines available in most countries. In this study, we explored the anti-RSV potential of 2, 4-Di-tert-butylphenol (2, 4-DTBP), a compound derived from Houttuynia cordata Thunb. To overcome the poor solubility of 2, 4-DTBP, we encapsulated it in polymeric micelles and delivered it by inhalation. We found that 2, 4-DTBP-loaded micelles inhibited RSV infection in vitro and improved survival, lung pathology, and viral clearance in RSV-infected mice. Our results suggested that 2, 4-DTBP-loaded micelle is a promising novel therapeutic agent for RSV infection.

Keywords: 2, 4-di-tert-butylphenol; Anti-virus; Human respiratory syncytial virus; In vitro; In vivo; Micelle.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Inhalation
  • Animals
  • Antiviral Agents* / administration & dosage
  • Antiviral Agents* / pharmacology
  • Antiviral Agents* / therapeutic use
  • Cell Line
  • Disease Models, Animal
  • Female
  • Houttuynia / chemistry
  • Humans
  • Lung / drug effects
  • Lung / pathology
  • Lung / virology
  • Mice
  • Mice, Inbred BALB C
  • Micelles*
  • Phenols / administration & dosage
  • Phenols / chemistry
  • Phenols / pharmacology
  • Phenols / therapeutic use
  • Respiratory Syncytial Virus Infections* / drug therapy
  • Respiratory Syncytial Virus, Human / drug effects