Invasive Candida Infection in Patients With Bacterial Infective Endocarditis

Travis Combs; Bobbi Jo Stoner; Parker McCoy; Hassan Reda; Michael Sekela; Sami El-Dalati

doi:10.1093/ofid/ofae179

Invasive Candida Infection in Patients With Bacterial Infective Endocarditis

Open Forum Infect Dis. 2024 Mar 26;11(4):ofae179. doi: 10.1093/ofid/ofae179. eCollection 2024 Apr.

Authors

Travis Combs¹, Bobbi Jo Stoner², Parker McCoy², Hassan Reda³, Michael Sekela³, Sami El-Dalati⁴

Affiliations

¹ Department of Internal Medicine, University of Kentucky College of Medicine, Lexington, Kentucky, USA.
² Department of Pharmacy, University of Kentucky College of Pharmacy, Lexington, Kentucky, USA.
³ Division of Cardiothoracic Surgery, Department of Surgery, University of Kentucky College of Medicine, Lexington, Kentucky, USA.
⁴ Division of Infectious Diseases, Department of Internal Medicine, University of Kentucky College of Medicine, Lexington, Kentucky, USA.

Abstract

Over 21 months, 12 patients with invasive Candida infections detected during the course of treatment of bacterial endocarditis, including 11 with candidemia, were identified. Invasive Candida infections can occur as a complication of bacterial endocarditis and may occur more frequently in patients with injection drug use and broad-spectrum antibiotic exposure.

Keywords: Candida infection; antimicrobial therapy; bacterial endocarditis; injection drug use.