Tet2 is a tumor suppressor in the preleukemic phase of T-cell acute lymphoblastic leukemia

Stien De Coninck; Juliette Roels; Béatrice Lintermans; Sara T'Sas; Tom Taghon; David J Curtis; Tim Pieters; Steven Goossens; Pieter Van Vlierberghe

doi:10.1182/bloodadvances.2023011970

Tet2 is a tumor suppressor in the preleukemic phase of T-cell acute lymphoblastic leukemia

Blood Adv. 2024 Jun 11;8(11):2646-2649. doi: 10.1182/bloodadvances.2023011970.

Authors

Stien De Coninck^{1

2

3}, Juliette Roels^{1

2

4}, Béatrice Lintermans^{1

2}, Sara T'Sas^{1

2

3}, Tom Taghon⁴, David J Curtis^{5

6}, Tim Pieters^{1

2

3

7}, Steven Goossens^{2

3}, Pieter Van Vlierberghe^{1

2}

Affiliations

¹ Department of Biomolecular Medicine, Laboratory of Normal and Malignant Hematopoiesis, Ghent University, Ghent, Belgium.
² Cancer Research Institute Ghent, Ghent, Belgium.
³ Department of Diagnostic Sciences, Unit for Translational Research in Oncology, Ghent University, Ghent, Belgium.
⁴ Department of Diagnostic Sciences, Taghon Laboratory, Ghent University, Ghent, Belgium.
⁵ Australian Centre for Blood Diseases, Central Clinical School, Monash University, Melbourne, VIC, Australia.
⁶ Department of Clinical Haematology, Alfred Hospital, Prahran, VIC, Australia.
⁷ Department of Biomolecular Medicine, Laboratory for research in oncogenesis and resistance to therapy, Ghent University, Ghent, Belgium.

No abstract available

MeSH terms

DNA-Binding Proteins* / genetics
DNA-Binding Proteins* / metabolism
Dioxygenases*
Genes, Tumor Suppressor
Humans
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma* / genetics
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma* / metabolism
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma* / pathology
Proto-Oncogene Proteins* / genetics
Proto-Oncogene Proteins* / metabolism

Substances

TET2 protein, human
Dioxygenases
Proto-Oncogene Proteins
DNA-Binding Proteins