Endothelial ZIP8 plays a minor role in BMP6 regulation by iron in mice

Blood. 2024 Jun 6;143(23):2433-2437. doi: 10.1182/blood.2023023385.

Abstract

Iron-mediated induction of bone morphogenetic protein (BMP)6 expression by liver endothelial cells is essential for iron homeostasis regulation. We used multiple dietary and genetic mouse cohorts to demonstrate a minor functional role for the metal-ion transporter ZIP8 in regulating BMP6 expression under high-iron conditions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Bone Morphogenetic Protein 6* / genetics
  • Bone Morphogenetic Protein 6* / metabolism
  • Cation Transport Proteins* / genetics
  • Cation Transport Proteins* / metabolism
  • Endothelial Cells / metabolism
  • Gene Expression Regulation
  • Homeostasis
  • Iron* / metabolism
  • Liver / metabolism
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout

Substances

  • Bone Morphogenetic Protein 6
  • Cation Transport Proteins
  • Iron
  • Bmp6 protein, mouse
  • Slc39a8 protein, mouse