Th2 response drives itch in dystrophic epidermolysis bullosa pruriginosa: A case-control study

Marieta Papanikolaou; Leigh Nattkemper; Natashia Benzian-Olsson; Lu Liu; Alyson Guy; Han Lu; Tendai Kadiyirire; Ping-Chen Hou; Wilson Aala; Sonia Serrano; Rashida Pramanik; Nina Walters; Konstantina Dimitrakopoulou; Su Lwin; Emily Kalfas; Jose Satoc; Roman Laddach; Domenico Cozzetto; Bjorn Thomas; Evangelia Kesidou; Ellie Rashidghamat; Guy Orchard; Edel A O'Toole; Chao-Kai Hsu; Mansoor Saqi; Martin Steinhoff; Alexandros Onoufriadis; Gil Yosipovitch; Hannah Gould; Jemima E Mellerio; John A McGrath

doi:10.1016/j.jaad.2024.01.088

Th2 response drives itch in dystrophic epidermolysis bullosa pruriginosa: A case-control study

J Am Acad Dermatol. 2024 Jul;91(1):130-133. doi: 10.1016/j.jaad.2024.01.088. Epub 2024 Mar 13.

Authors

Marieta Papanikolaou¹, Leigh Nattkemper², Natashia Benzian-Olsson³, Lu Liu⁴, Alyson Guy⁴, Han Lu⁵, Tendai Kadiyirire³, Ping-Chen Hou⁶, Wilson Aala⁷, Sonia Serrano⁸, Rashida Pramanik⁸, Nina Walters³, Konstantina Dimitrakopoulou⁸, Su Lwin³, Emily Kalfas³, Jose Satoc⁹, Roman Laddach³, Domenico Cozzetto⁸, Bjorn Thomas¹⁰, Evangelia Kesidou³, Ellie Rashidghamat³, Guy Orchard⁹, Edel A O'Toole¹⁰, Chao-Kai Hsu¹¹, Mansoor Saqi⁸, Martin Steinhoff¹², Alexandros Onoufriadis¹³, Gil Yosipovitch², Hannah Gould¹⁴, Jemima E Mellerio³, John A McGrath³

Affiliations

¹ St John's Institute of Dermatology, School of Basic and Medical Biosciences, King's College London, London, UK. Electronic address: marieta.papanikolaou@kcl.ac.uk.
² Dr. Phillip Frost Department of Dermatology & Cutaneous Surgery and Miami Itch Center, University of Miami Miller School of Medicine, Miami, Florida.
³ St John's Institute of Dermatology, School of Basic and Medical Biosciences, King's College London, London, UK.
⁴ The Robin Eady National Diagnostic Epidermolysis Bullosa Laboratory, Synnovis, Guy's Hospital, London, UK.
⁵ King's Genomics Center, Franklin-Wilkins Building, Waterloo Campus, King's College London, London, UK.
⁶ Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
⁷ Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
⁸ NIHR Biomedical Research Center, Guy's & St Thomas' NHS Foundation Trust and King's College London, London, UK.
⁹ Dermatopathology Laboratory, Synnovis, St Thomas' Hospital, London, UK.
¹⁰ Center for Cell Biology and Cutaneous Research, Blizard Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK.
¹¹ Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan; International Research Center of Wound Repair and Regeneration (iWRR), National Cheng Kung University, Tainan, Taiwan.
¹² Department of Dermatology and Translational Research Institute, Hamad Medical Corporation, Weill Cornell Medicine-Qatar, Doha, Qatar.
¹³ St John's Institute of Dermatology, School of Basic and Medical Biosciences, King's College London, London, UK; Laboratory of Medical Biology and Genetics, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.
¹⁴ Randall Center for Cell and Molecular Biophysics and School of Basic and Medical Biosciences, King's College London, London, UK.

PMID: 38484894
DOI: 10.1016/j.jaad.2024.01.088

No abstract available

Keywords: RNA sequencing; Th2; dystrophic epidermolysis bullosa; itch; pruriginosa; pruritus.

Publication types

Letter

MeSH terms

Adolescent
Adult
Case-Control Studies
Epidermolysis Bullosa Dystrophica* / complications
Female
Humans
Male
Middle Aged
Pruritus* / etiology
Young Adult

Supplementary concepts

Epidermolysis Bullosa Pruriginosa