Persistent Gram-negative Bloodstream Infection Increases the Risk of Recurrent Bloodstream Infection With the Same Species

Clin Infect Dis. 2024 Jun 14;78(6):1458-1461. doi: 10.1093/cid/ciae068.

Abstract

The association between persistent gram-negative bloodstream infection (GN-BSI), or ongoing positive cultures, and recurrent GN-BSI has not been investigated. Among 992 adults, persistent GN-BSI was associated with increased recurrent GN-BSI with the same bacterial species and strain (6% vs 2%; P = .04). Persistent GN-BSI may be a marker of complicated infection.

Keywords: bloodstream infection; gram-negative; recurrent; reinfection; relapse.

MeSH terms

  • Adult
  • Aged
  • Bacteremia* / epidemiology
  • Bacteremia* / microbiology
  • Female
  • Gram-Negative Bacteria* / classification
  • Gram-Negative Bacteria* / isolation & purification
  • Gram-Negative Bacterial Infections* / epidemiology
  • Gram-Negative Bacterial Infections* / microbiology
  • Humans
  • Male
  • Middle Aged
  • Recurrence*
  • Risk Factors