The landscape of fetus metabolism in maternal hyperglycemia

Miranda E Kelly; Thomas F Martinez; Cholsoon Jang

doi:10.1016/j.tem.2024.01.012

The landscape of fetus metabolism in maternal hyperglycemia

Trends Endocrinol Metab. 2024 Apr;35(4):282-284. doi: 10.1016/j.tem.2024.01.012. Epub 2024 Feb 9.

Authors

Miranda E Kelly¹, Thomas F Martinez², Cholsoon Jang³

Affiliations

¹ Department of Biological Chemistry, Chao Family Comprehensive Cancer Center, University of California Irvine School of Medicine, Irvine, CA 92697-4025, USA.
² Department of Biological Chemistry, Chao Family Comprehensive Cancer Center, University of California Irvine School of Medicine, Irvine, CA 92697-4025, USA; Department of Pharmaceutical Sciences, University of California, Irvine, Irvine, CA 92697-4025, USA.
³ Department of Biological Chemistry, Chao Family Comprehensive Cancer Center, University of California Irvine School of Medicine, Irvine, CA 92697-4025, USA. Electronic address: choljang@uci.edu.

Abstract

Maternal hyperglycemia contributes to abnormal fetal development; yet, how it affects fetal metabolism is poorly understood. Perez-Ramirez and colleagues recently provided a comprehensive metabolic atlas of fetal organs isolated from normal and diabetic pregnant mice, identifying novel metabolites and alterations in tissue glucose utilization throughout mid-to-late gestation by maternal hyperglycemia.

MeSH terms

Animals
Diabetes, Gestational*
Female
Fetal Development
Fetus / metabolism
Glucose / metabolism
Humans
Hyperglycemia* / metabolism
Mice
Pregnancy

Substances

Glucose

Grants and funding

R01 AA029124/AA/NIAAA NIH HHS/United States