Footprint of publication selection bias on meta-analyses in medicine, environmental sciences, psychology, and economics

Res Synth Methods. 2024 May;15(3):500-511. doi: 10.1002/jrsm.1703. Epub 2024 Feb 7.

Abstract

Publication selection bias undermines the systematic accumulation of evidence. To assess the extent of this problem, we survey over 68,000 meta-analyses containing over 700,000 effect size estimates from medicine (67,386/597,699), environmental sciences (199/12,707), psychology (605/23,563), and economics (327/91,421). Our results indicate that meta-analyses in economics are the most severely contaminated by publication selection bias, closely followed by meta-analyses in environmental sciences and psychology, whereas meta-analyses in medicine are contaminated the least. After adjusting for publication selection bias, the median probability of the presence of an effect decreased from 99.9% to 29.7% in economics, from 98.9% to 55.7% in psychology, from 99.8% to 70.7% in environmental sciences, and from 38.0% to 29.7% in medicine. The median absolute effect sizes (in terms of standardized mean differences) decreased from d = 0.20 to d = 0.07 in economics, from d = 0.37 to d = 0.26 in psychology, from d = 0.62 to d = 0.43 in environmental sciences, and from d = 0.24 to d = 0.13 in medicine.

Keywords: Bayesian; RoBMA; effect sizes; evidence; meta‐analysis; model‐averaging; publication bias.

MeSH terms

  • Ecology
  • Economics*
  • Humans
  • Medicine
  • Meta-Analysis as Topic*
  • Probability
  • Psychology*
  • Publication Bias*
  • Research Design
  • Selection Bias