Isolated massive pleural effusion as a manifestation of chronic graft versus host disease successfully treated with corticosteroid

Ann Hematol. 2024 Apr;103(4):1403-1407. doi: 10.1007/s00277-024-05643-w. Epub 2024 Jan 29.

Abstract

Isolated pleural effusion is a rare manifestation of chronic graft versus host disease (cGVHD) after hematopoietic stem cell transplantation (HSCT). We herein report a 58-year-old woman presenting with massive pleural effusion approximately 1 year after allogeneic HSCT, who was successfully treated with corticosteroid. She had discontinued tacrolimus approximately 1 month before she presented with pleural effusion, which was attributed to cGVHD after a thorough exclusion process. This case illustrates a unique manifestation of atypical cGVHD and highlights the need for prompt therapy initiation.

Keywords: Allogeneic hematopoietic stem cell transplant; Chronic graft versus host disease; Pleural effusion.

Publication types

  • Case Reports

MeSH terms

  • Adrenal Cortex Hormones / therapeutic use
  • Bronchiolitis Obliterans Syndrome*
  • Chronic Disease
  • Female
  • Graft vs Host Disease* / drug therapy
  • Graft vs Host Disease* / etiology
  • Hematopoietic Stem Cell Transplantation* / adverse effects
  • Humans
  • Middle Aged
  • Pleural Effusion* / drug therapy
  • Pleural Effusion* / etiology
  • Tacrolimus / therapeutic use

Substances

  • Adrenal Cortex Hormones
  • Tacrolimus