Making glaucoma genetic studies more diverse

David A Mackey; Sandra E Staffieri

doi:10.1016/j.cell.2023.12.023

Making glaucoma genetic studies more diverse

Cell. 2024 Jan 18;187(2):273-275. doi: 10.1016/j.cell.2023.12.023.

Authors

David A Mackey¹, Sandra E Staffieri²

Affiliations

¹ Lions Eye Institute, University of Western Australia, Perth, WA, Australia; Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia. Electronic address: d.mackey@utas.edu.au.
² Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, VIC, Australia; Ophthalmology, Department of Surgery, University of Melbourne, Parkville, VIC, Australia.

PMID: 38242084
DOI: 10.1016/j.cell.2023.12.023

Abstract

Although the blinding eye disease glaucoma is more common in people of African ancestry, previous genetic studies predominantly involved European subjects. In this issue of Cell, O'Brien et al. report a genome-wide association study for glaucoma in individuals of African ancestry, showing overlap with European studies and refining an African polygenic risk score.

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MeSH terms

Black People / genetics
Genetic Predisposition to Disease
Genome-Wide Association Study*
Glaucoma* / genetics
Humans
Polymorphism, Single Nucleotide
Research