Eighteen iridoids from the roots and rhizomes of Valeriana jatamansi and their protective effects against α-hemolysin

Yao Zhu; Peng-Ju Guo; Ao-Xue Ding; Liu Zheng; Gao-Xiang Du; Tong Chen; Guo-Qing Qin; Xiang-Gang Hu; Wen-Qiong Wang; Li-Jiang Xuan

doi:10.1016/j.phytochem.2023.113962

Eighteen iridoids from the roots and rhizomes of Valeriana jatamansi and their protective effects against α-hemolysin

Phytochemistry. 2024 Mar:219:113962. doi: 10.1016/j.phytochem.2023.113962. Epub 2024 Jan 5.

Authors

Affiliations

¹ State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai, 201203, China; University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing, 100049, China.
² State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai, 201203, China; School of Pharmacy, Fudan University, Shanghai, 201203, China.
³ State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai, 201203, China; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210029, China.
⁴ State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai, 201203, China. Electronic address: wenqiong1019@126.com.
⁵ State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai, 201203, China; University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing, 100049, China; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210029, China. Electronic address: ljxuan@simm.ac.cn.

PMID: 38185394
DOI: 10.1016/j.phytochem.2023.113962

Abstract

Thirteen previously undescribed iridoids (1-13), together with five known iridoids (14-18) were isolated from the roots and rhizomes of Valeriana jatamansi Jones. Their structures with absolute configurations were elucidated by analysis of MS, NMR, optical rotation and their experimental and calculated electronic circular dichroism spectra. All of the isolated compounds were tested for their protective effects against α-hemolysin-induced cell death in A549 cells. Compounds 14, 16 and 17 showed moderate protective effects, and compounds 15 and 18 showed weak protective effects.

Keywords: Iridoids; Protective effects; Valeriana jatamansi Jones; α-hemolysin.

MeSH terms

Hemolysin Proteins / analysis
Iridoids / chemistry
Iridoids / pharmacology
Molecular Structure
Nardostachys*
Plant Roots / chemistry
Rhizome
Valerian* / chemistry

Substances

Hemolysin Proteins
Iridoids