Objective: To investigate the clinical and pathologic features and diagnosis of follicular lymphoma (FL) with a predominantly diffuse growth pattern (DFL) with 1p36 deletion. Methods: Eight cases of DFL with 1p36 deletion diagnosed at Department of Pathology, Beijing Friendship Hospital, Capital Medical University (n=5) and the Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital (n=3) from January 2017 to January 2023 were included. Their clinicopathologic features and follow-up data were analyzed. Immunohistochemistry and fluorescence in situ hybridization (FISH) were performed. Results: There were five males and three females, with a median age of 67 years, and inguinal lymphadenopathy was found as the main symptom. Histologically, similar morphologic features were sheared among all cases, with effaced nodal structure and characterized by proliferation of centrocytes in a diffuse pattern, with or without follicular components. The germinal center-related markers such as CD10 and/or bcl-6 were expressed in the tumor cells, and 1p36 deletion but not bcl-2 translocation was appreciable in these cases. Conclusions: DFL with 1p36 deletion is a rare subtype of FL, with some overlaps with other types of FL or indolent B-cell lymphomas in their pathologic features. An accurate diagnosis requires comprehensive considerations based on their clinical, pathologic, immunohistochemical, and molecular features.
目的： 探讨弥漫性生长为主的滤泡性淋巴瘤（DFL）伴1p36缺失的临床病理特点。 方法： 收集2017年1月至2023年1月首都医科大学附属北京友谊医院（5例）和河南省肿瘤医院（3例）诊断为DFL伴1p36缺失病例的临床资料并随访，总结形态学特点，进行免疫标记和荧光原位杂交检测，结合文献和诊断经验进行讨论。 结果： 8例患者，男性5例，女性3例，中位年龄67岁，以腹股沟淋巴结肿大为主要特点。本组8例病理形态学基本类似，表现为正常淋巴结结构破坏，肿瘤以弥漫生长的中心样细胞增生为主，伴或不伴局灶滤泡性结构为特征。瘤细胞表达CD10和/或bcl-6等生发中心标志物，荧光原位杂交检测示1p36缺失但无bcl-2易位。 结论： DFL伴1p36缺失是一组少见的滤泡性淋巴瘤亚型，病理学特点与其他类型的滤泡性淋巴瘤和低级别B细胞淋巴瘤存在一定程度的重叠；准确诊断需要结合临床特点、病理形态、免疫组织化学和相关分子检测进行综合判断。.