Temporal changes in the positivity rate of common enteric viruses among paediatric admissions in coastal Kenya, during the COVID-19 pandemic, 2019-2022

Arnold W Lambisia; Nickson Murunga; Martin Mutunga; Robinson Cheruiyot; Grace Maina; Timothy O Makori; D James Nokes; Charles N Agoti

doi:10.1186/s13099-023-00595-4

Temporal changes in the positivity rate of common enteric viruses among paediatric admissions in coastal Kenya, during the COVID-19 pandemic, 2019-2022

Gut Pathog. 2024 Jan 4;16(1):2. doi: 10.1186/s13099-023-00595-4.

Authors

Arnold W Lambisia¹, Nickson Murunga², Martin Mutunga², Robinson Cheruiyot², Grace Maina², Timothy O Makori², D James Nokes^{2

3}, Charles N Agoti^{2

4}

Affiliations

¹ Kenya Medical Research Institute (KEMRI) - Wellcome Trust Research Programme (KWTRP), P.O. Box 230, Kilifi, 80108, Kenya. alambisia@kemri-wellcome.org.
² Kenya Medical Research Institute (KEMRI) - Wellcome Trust Research Programme (KWTRP), P.O. Box 230, Kilifi, 80108, Kenya.
³ School of Life Sciences and Zeeman Institute for Systems Biology and Infectious Disease Epidemiology Research (SBIDER), University of Warwick, Coventry, CV4 7AL, UK.
⁴ Department of Public Health, Pwani University, P.O. Box 195, Kilifi, 80108, Kenya.

Abstract

Background: The non-pharmaceutical interventions (NPIs) implemented to curb the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) early in the coronavirus disease 2019 (COVID-19) pandemic, substantially disrupted the activity of other respiratory viruses. However, there is limited data from low-and-middle income countries (LMICs) to determine whether these NPIs also impacted the transmission of common enteric viruses. Here, we investigated the changes in the positivity rate of five enteric viruses among hospitalised children who presented with diarrhoea to a referral hospital in coastal Kenya, during COVID-19 pandemic period.

Methods: A total of 870 stool samples from children under 13 years of age admitted to Kilifi County Hospital between January 2019, and December 2022 were screened for rotavirus group A (RVA), norovirus genogroup II (GII), astrovirus, sapovirus, and adenovirus type F40/41 using real-time reverse-transcription polymerase chain reaction. The proportions positive across the four years were compared using the chi-squared test statistic.

Results: One or more of the five virus targets were detected in 282 (32.4%) cases. A reduction in the positivity rate of RVA cases was observed from 2019 (12.1%, 95% confidence interval (CI) 8.7-16.2%) to 2020 (1.7%, 95% CI 0.2-6.0%; p < 0.001). However, in the 2022, RVA positivity rate rebounded to 23.5% (95% CI 18.2%-29.4%). For norovirus GII, the positivity rate fluctuated over the four years with its highest positivity rate observed in 2020 (16.2%; 95% C.I, 10.0-24.1%). No astrovirus cases were detected in 2020 and 2021, but the positivity rate in 2022 was similar to that in 2019 (3.1% (95% CI 1.5%-5.7%) vs. 3.3% (95% CI 1.4-6.5%)). A higher case fatality rate was observed in 2021 (9.0%) compared to the 2019 (3.2%), 2020 (6.8%) and 2022 (2.1%) (p < 0.001).

Conclusion: Our study finds that in 2020 the transmission of common enteric viruses, especially RVA and astrovirus, in Kilifi Kenya may have been disrupted due to the COVID-19 NPIs. After 2020, local enteric virus transmission patterns appeared to return to pre-pandemic levels coinciding with the removal of most of the government COVID-19 NPIs.

Keywords: Adenovirus F40/41; Astrovirus; COVID-19; Kenya; Norovirus GII; Paediatrics; Positivity rate; Rotavirus group A; Sapovirus.

Abstract

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