Due to the advancement of 16S rRNA sequencing technology, the lower respiratory tract microbiota, which was considered non-existent, has been revealed. The correlation between these microorganisms and diseases such as tumor has been a hot topic in recent years. As the bacteria in the surrounding can infiltrate the tumors, researchers have also begun to pay attention to the biological behavior of tumor bacteria and their interaction with tumors. In this review, we present the characteristic of the lower respiratory tract bacteria and summarize recent research findings on the relationship between these microbiota and lung cancer. On top of that, we also summarize the basic feature of bacteria in tumors and focus on the characteristic of the bacteria in lung cancer. The relationship between bacteria in lung cancer and tumor development is also been discussed. Finally, we review the potential clinical applications of bacterial communities in the lower respiratory tract and lung cancer, and summarize key points of sample collection, sequencing, and contamination control, hoping to provide new ideas for the screening and treatment of tumors. .
【中文题目：下呼吸道及肺癌内菌群与肺癌发生发展的 关系及其临床应用】 【中文摘要：由于16S rRNA测序技术的发展，长期以来被认为是不存在的下呼吸道菌群也逐步被揭示出来。这些微生物与疾病（如肿瘤）的相关性是近年来的研究热点。由于肿瘤周围环境中的菌群会进入肿瘤内部，研究者们也开始关注肿瘤内菌群的生物学行为以及其与肿瘤的相互作用。在这篇综述中，我们展示了下呼吸道菌群的特点，并总结了近年来关于这些菌群与肺癌关系的相关研究成果。同时，我们也对肿瘤内菌群的基本特征进行整理，并着重阐述肺癌内菌群的特点及其与肺癌发生、发展的关系。最后，我们综述了下呼吸道和肺癌内菌群在临床上的转化应用方向，并汇总了样本采集、测序和控制污染的要点，希望为肿瘤的早筛和治疗提供新的思路。 】 【中文关键词：肺肿瘤；呼吸系统；细菌】.
Keywords: Bacteria; Lung neoplasms; Respiratory system.