Our recent study revealed that APOBEC3B is upregulated during the preinvasive stages of non-small cell lung cancer and breast cancer. In addition to its role in mediating single nucleotide variants, we propose that APOBEC3 promotes copy number intratumor heterogeneity prior to invasion, providing a substrate for cancer evolution.
Keywords: APOBEC; breast cancer; chromosomal instability; intratumor heterogeneity; non-small cell lung cancer.
© 2021 The Author(s). Published with license by Taylor & Francis Group, LLC.