MRI-Guided Adaptive Radiation Therapy

Cecil M Benitez; Michael D Chuong; Luise A Künzel; Daniela Thorwarth

doi:10.1016/j.semradonc.2023.10.013

MRI-Guided Adaptive Radiation Therapy

Semin Radiat Oncol. 2024 Jan;34(1):84-91. doi: 10.1016/j.semradonc.2023.10.013.

Authors

Cecil M Benitez¹, Michael D Chuong², Luise A Künzel³, Daniela Thorwarth⁴

Affiliations

¹ Department of Radiation Oncology, UCLA Medical Center, Los Angeles, CA.
² Department of Radiation Oncology, Miami Cancer Institute, Baptist Health South Florida; Miami, FL.
³ National Center for Tumor Diseases (NCT), Dresden; German Cancer Research Center (DKFZ), Heidelberg; Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden; Helmholtz-Zentrum Dresden - Rossendorf (HZDR), Dresden, Germany; Department of Radiotherapy and Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.; OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden Rossendorf, Dresden, Germany.
⁴ Department of Radiation Oncology, Section for Biomedical Physics, University of Tübingen, Tübingen, Germany.. Electronic address: Daniela.Thorwarth@med.uni-tuebingen.de.

PMID: 38105097
DOI: 10.1016/j.semradonc.2023.10.013

Abstract

Magnetic resonance imaging-guided radiation therapy (MRIgRT) has improved soft tissue contrast over computed tomography (CT) based image-guided RT. Superior visualization of the target and surrounding radiosensitive structures has the potential to improve oncological outcomes partly due to safer dose-escalation and adaptive planning. In this review, we highlight the workflow of adaptive MRIgRT planning, which includes simulation imaging, daily MRI, identifying isocenter shifts, contouring, plan optimization, quality control, and delivery. Increased utilization of MRIgRT will depend on addressing technical limitations of this technology, while addressing treatment efficacy, cost-effectiveness, and workflow training.

Publication types

Review

MeSH terms

Humans
Magnetic Resonance Imaging / methods
Radiotherapy Planning, Computer-Assisted* / methods
Radiotherapy, Image-Guided* / methods
Tomography, X-Ray Computed