Microglia dynamic response and phenotype heterogeneity in neural regeneration following hypoxic-ischemic brain injury

Hongxin Quan; Runrui Zhang

doi:10.3389/fimmu.2023.1320271

Microglia dynamic response and phenotype heterogeneity in neural regeneration following hypoxic-ischemic brain injury

Front Immunol. 2023 Nov 29:14:1320271. doi: 10.3389/fimmu.2023.1320271. eCollection 2023.

Authors

Hongxin Quan^{1

2}, Runrui Zhang^{1

2}

Affiliations

¹ State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, Yunnan, China.
² Yunnan Key Laboratory of Primate Biomedical Research, Kunming, Yunnan, China.

Abstract

Hypoxic-ischemic brain injury poses a significant threat to the neural niche within the central nervous system. In response to this pathological process, microglia, as innate immune cells in the central nervous system, undergo rapid morphological, molecular and functional changes. Here, we comprehensively review these dynamic changes in microglial response to hypoxic-ischemic brain injury under pathological conditions, including stroke, chronic intermittent hypoxia and neonatal hypoxic-ischemic brain injury. We focus on the regulation of signaling pathways under hypoxic-ischemic brain injury and further describe the process of microenvironment remodeling and neural tissue regeneration mediated by microglia after hypoxic-ischemic injury.

Keywords: hypoxic-ischemic brain injury; microglia dynamic response; microglia heterogeneity; neural regeneration; neurogenesis.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Brain Injuries* / metabolism
Humans
Hypoxia / metabolism
Hypoxia-Ischemia, Brain* / metabolism
Microglia / metabolism
Nerve Regeneration
Phenotype

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by the National Natural Science Foundation of China (NSFC) (32070864), Xingdian Talent Support Program (KKRD202273100), Major Basic Research Project of Science and Technology of Yunnan (202101AT070287).