Incubation as a driver of maternal effects: Temperature influences levels of yolk maternally derived 5α-dihydrotestosterone

Gen Comp Endocrinol. 2024 Feb 1:347:114420. doi: 10.1016/j.ygcen.2023.114420. Epub 2023 Dec 12.

Abstract

In birds, maternal hormones deposited into eggs in response to environmental stimuli can impact offspring phenotype. Although less studied, environmental conditions can also influence females' incubation behavior, which might play a role in regulating embryo exposure to maternal hormones through changes in incubation temperature that affect the activity of the enzymes responsible for converting testosterone (T) to 5α-dihydrotestosterone (DHT) or estradiol. Here, we tested the hypothesis that the initial T content of the yolk and incubation temperature determine exposure to T metabolites during early embryo development. In the Japanese quail (Coturnix japonica), we experimentally manipulated yolk T and incubation temperature (38° C versus 36° C) and analyzed DHT and estradiol titers on day four of incubation. We found that eggs with experimentally increased T and those incubated at 36° C showed higher DHT concentration in egg yolk (with no synergistic effect of the two treatments). Estradiol titers were not affected by T manipulation or incubation temperature. Our study suggests that incubation temperature influences DHT titers and may act as an understudied source of maternal influence on offspring phenotype.

Keywords: DHT; Incubation behavior; Maternal care; Non-hormonal maternal effects.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Coturnix* / physiology
  • Dihydrotestosterone* / metabolism
  • Egg Yolk / metabolism
  • Estradiol / metabolism
  • Female
  • Maternal Inheritance
  • Temperature
  • Testosterone / metabolism

Substances

  • Dihydrotestosterone
  • Testosterone
  • Estradiol